Botulinum Toxin Type A
(Botox Cosmetic) is a protein complex which is produced by the bacterium Clostridium botulinum. When
Botox
® is used cosmetically as an injectable form of sterile, purified botulinum toxin, minor doses inhibit the release of a chemical called acetylcholine by nerve cells that signal the muscle to tighten. By selectively interfering with the underlying muscles' ability to contract, existing frown lines are smoothed out and, in most cases, are nearly invisible in a week.
Botox ® injections are the fastest-growing non-surgical cosmetic procedures in the industry, according to the American Society for Aesthetic Plastic Surgery (ASAPS). In 2001alone, more than 1.6 million people received injections, which is an increase of 46 percent from 2000. Botox ® treatments have become more popular than breast augmentation, and it's popularity continues to grow because of it's fast and almost instant results. Many people who have Botox ® treatment's consider it the ultimate fountain of youth.
Botox ® injections are the fastest-growing non-surgical cosmetic procedures in the industry, according to the American Society for Aesthetic Plastic Surgery (ASAPS). In 2001alone, more than 1.6 million people received injections, which is an increase of 46 percent from 2000. Botox ® treatments have become more popular than breast augmentation, and it's popularity continues to grow because of it's fast and almost instant results. Many people who have Botox ® treatment's consider it the ultimate fountain of youth.
Authorized healthcare professionals familiar with facial anatomy such as dermatologists, plastic surgeons, ophthalmologists, otolaryngologists(ENT's), or other physicians who specialize in cosmetic procedures can administer
BOTOX
®. Any one of these physicians can help you decide if
BOTOX
® is the appropriate treatment for you. In certain states, registered nurses can administer Botox® injections as directed by a physician or other authorized prescriber, only after the patient has been examined by the physician.
BOTOX
® is indicated for the treatment of cervical dystonia (involuntary contractions of neck muscles which cause abnormal movements and posture of the head and neck) in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia.
Botox ® was approved for this indication by the FDA on 4/12/2002.
BOTOX ® is indicated for the treatment of severe primary axillary hyperhidrosis(exsessive sweating) that is inadequately managed with topical agents. This indication for Botox ® was approved by the FDA in July of 2004.
BOTOX ® is indicated for the treatment of strabismus (crossed eyes) and blepharospasm associated with dystonia, including benign essential blepharospasm or VII nerve disorders in patients 12 years of age and above. This indication was approved by the FDA in December 1989.
Botox ® was approved for this indication by the FDA on 4/12/2002.
BOTOX ® is indicated for the treatment of severe primary axillary hyperhidrosis(exsessive sweating) that is inadequately managed with topical agents. This indication for Botox ® was approved by the FDA in July of 2004.
BOTOX ® is indicated for the treatment of strabismus (crossed eyes) and blepharospasm associated with dystonia, including benign essential blepharospasm or VII nerve disorders in patients 12 years of age and above. This indication was approved by the FDA in December 1989.
Botox
® is indicated to temporarily improve the appearance of moderate to severe frown lines between the eyebrows (glabellar lines), a medical condition that is not serious. This indication for
Botox
® was approved by the FDA in April of 2002.
The efficacy of BOTOX ® treatment in deviations over 50 prism diopters, in restrictive strabismus, in Duane's syndrome with lateral rectus weakness, and in secondary strabismus caused by prior surgical over-recession of the antagonist has not been established. BOTOX ® is ineffective in chronic paralytic strabismus except when used in conjunction with surgical repair to reduce antagonist contracture.
The efficacy of BOTOX ® treatment in deviations over 50 prism diopters, in restrictive strabismus, in Duane's syndrome with lateral rectus weakness, and in secondary strabismus caused by prior surgical over-recession of the antagonist has not been established. BOTOX ® is ineffective in chronic paralytic strabismus except when used in conjunction with surgical repair to reduce antagonist contracture.
Off- Label Use ( fromFDA SPLA 9 1-O 184 Response to CR Letter Allergan, Inc.)
There is considerable use of Botox ® in the U.S for indications other than those described in the label. In 1990 a Consensus Conference convened by NIH discussed the clinical uses of botulinum toxin. This consensus conference endorsed the use of botulinurn toxin in the disorders described in the U.S. label for BOTOX ® , but also endorsed its use in cervical dystonia, Meige syndrome (orofacial dystonia), and encouraged further investigations in several additional disorders. Since that time, numerous reports have appeared in the medical literature supporting toxin use in other focal and segmental dystonias, limb spasticity, GI disorders such as achalasia and anismus, and cosmetic use for reduction of frown lines and other facial skin folds.
There is considerable use of Botox ® in the U.S for indications other than those described in the label. In 1990 a Consensus Conference convened by NIH discussed the clinical uses of botulinum toxin. This consensus conference endorsed the use of botulinurn toxin in the disorders described in the U.S. label for BOTOX ® , but also endorsed its use in cervical dystonia, Meige syndrome (orofacial dystonia), and encouraged further investigations in several additional disorders. Since that time, numerous reports have appeared in the medical literature supporting toxin use in other focal and segmental dystonias, limb spasticity, GI disorders such as achalasia and anismus, and cosmetic use for reduction of frown lines and other facial skin folds.
There are numerous other "off-label" uses for
Botox®
that are currently being employed to help aleviate symptoms associated with other common conditions such as: Multiple Sclerosis, Schilder's disease, Central demyelinating of corpus callosum, Hereditary spastic paraplegia, Anal fissures, Migraines, Tourette syndrome, low back pain, spasmodic dysphonia (which results in speech that is difficult to understand), urinary bladder muscle relaxation (such as in cases where muscle contraction is severe enough to require catheterized urination) and Piriformis syndrome.
An important difference in these uses is that the risk benefit comparison has not been as well documented to date, and may involve usage in a manner inherently more risky. Cervical dystonia is perhaps the most clear example of this. Reported doses of toxin used for cervical dystonia are up to 5 times higher than typical doses for blepharospasm, and are injected into a region surrounding the pharynx, placing adequate pharyngeal function at specific risk.
Possible Adverse Effects from Botox
®
injections
As with any medical treatment, the potential for adverse effects can be a major issue. One must explore the risk/ benefit issues prior to any medical procedure. As per Allergan, Inc. there have been rare spontaneous reports of death, sometimes associated with dysphagia, pneumonia, and/or other significant debility or anaphylaxis, after treatment with botulinum toxin. Other reported side effects involve the cardiovascular system, some with fatal outcomes. Relatively minor and localized reactions have benn reported such as rash, and hives.
In general, adverse events occur within the first week following injection of
BOTOX
® and while generally transient may have a duration of several months. Localized pain, tenderness and/or bruising may be associated with the injection. Local weakness of the injected muscle(s) represents the expected pharmacological action of botulinum toxin. However, weakness of adjacent muscles may also occur due to spread of toxin, read more...
Is Botox
®
right for you?
Not all patients who request a nonsurgical cosmetic procedure such as
Botox
®, is an appropriate candidate for one. Potential patients should undergo a prescreening that includes a visit with the physician, a thorough history, and a physical examination to determine the suitability of the proposed treatment with Botox. The Do'sand Don'ts of
Botox
, read article.
BOTOX® is a registered trademark owned by Allergan. This website is in no way affiliated with Allergan.
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